#5590 PRE-DIALYSIS TRAJECTORIES OF ESTIMATED GFR AND CONCURRENT TRENDS OF CKD-RELEVANT BIOMARKERS

Abstract Background and Aims The glomerular filtration rate (GFR) decline varies in patients with advanced chronic kidney disease (CKD), the concurrent changes CKD-related biomarkers are unclear. Method We adopted a group-based trajectory model to categorize CKD by their pre-dialysis eGFR then analyzed changing trends of CKD-relevant biomarkers, including urine protein-creatinine ratio (UPCR), albumin, uric acid. Results Using longitudinal data from two years before dialysis initiation, 1,758 were included. identified three distinct trajectories: persistently low levels, progressive loss eGFR, accelerated eGFR. Eight 15 showed patterns among groups. Compared group values, other groups associated more rapid increase serum urea level UPCR, especially year hemoglobin platelet counts. Rapid was lower levels albumin potassium, higher MCHC WBC. an below normal range. Overall, there total 691 (39.3%) deaths observed during follow-up period. In 2-year 5-year follow-up, 302 (17.2%) 549 (31.2%) observed, respectively. corresponding median times 2 (IQR:1.6 – 2.0) 3.3 –5.0). Kaplan–Meier survival plots that significantly risk mortality five after dialysis, log-rank test P = .0057 .0001, respectively Conclusion delineated progression. results provide information clinicians clues elucidate mechanism